Made by GENEXPHARMA (This item ships from Canada!)
Human chorionic gonadotropin
5000IU x 1 vial (Solvent is NOT included)
Human chorionic gonadotropin (hCG, Pregnyl, Choragon) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the syncytiotrophoblast (part of the placenta). Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans.
Because of its similarity to LH, hCG can also be used clinically to induce ovulation in the ovaries as well as testosterone production in the testes. As the most abundant biological source is women who are presently pregnant, some organizations collect urine from gravidae to extract hCG for use in fertility treatment.
In the male, hCG injections are used to stimulate the leydig cells to synthesize testosterone. The intratesticular testosterone is necessary for spermatogenesis from the sertoli cells. Typical uses for hCG in men include hypogonadism and fertility treatment.
In the world of performance enhancing drugs, hCG is increasingly used in combination with various Anabolic Androgenic Steroid (AAS) cycles.
When AAS are put into a male body, the body’s natural negative feedback loops cause the body to shut down its own production of testosterone via shutdown of the HPTA (hypothalamic-pituitary-testicular axis). High levels of AASs that mimic the body’s natural testosterone trigger the hypothalamus to shut down its production of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Without GnRH the pituitary gland stops releasing luteinizing hormone (LH). LH normally travels from the pituitary via the blood stream to the testes where it triggers the production and release of testosterone. Without LH, the testes shut down their production of testosterone, causing testicular atrophy.
A gonadotropin is any substance that stimulates the gonads (ovary, testes). It is heterodimeric (initiates prophase of mitosis) with an alpha subunit identical to LH (luteinizing hormone), FSH (follicle stimulating hormone) and TSH (thyroid stimulating hormone). LH is as stated above is called a gonadotropin because it stimulates the gonads (testes). It is produced in the pituitary cells and is made up of a beta chain of 115 amino acids and an alpha chain of 89 amino acids. In the testes, the LH binds to receptors on the leydig cells which in turn stimulate the synthesis and secretion of testosterone. Like LH, FSH is also called a gonadotropin. It consists of a beta chain of 115 amino acids and an alpha chain of 89 amino acids, the same as LH. Production and release of FSH is controlled by GnRH (gonadotropin releasing hormone). FSH stimulates testicular growth and supports the function of sertoli cells, which are needed for sustaining maturing sperm cells.
HCG in males is similar to LH, because they are similar and LH binds to receptors on leydig cells stimulating synthesis and secretion of testosterone, the use of HCG would be an added bonus to ASS users even if there is a lack of endogenous LH. Since HCG increases the body´s natural testosterone levels its use during long or extremely high dosed cycles can be most beneficial were the effects on the hypothalamus causes a depressed signal to the testicles. The result of the depressed signal leads to what is known as testicular atrophy (shrunken nuts). The use of HCG will send an artificial signal to the testes (again, as if it were actually LH), thus preventing (to some degree) atrophy. It not only helps to maintain testicular size and condition but it will also help in restoring testicles back to their original size. At a time when below normal androgen levels (due to ASS use) could become costly. Restarting natural testosterone production as quickly as possible is of a special concern in males at the end of a cycle of AAS. The price paid by bodybuilders for failing to raise natural test levels is the loss of most if not all the hard earned muscle you have gained, the main cause is cortisol. Cortisol sends a message to the muscles that is opposite to that of testosterone. If cortisol is not dealt with (because of an extremely low testosterone level) it will quickly strip away the new and hard earned muscle you have just gotten.
Some users find that they have better gains and quicker recovery while using HCG during a cycle of AAS. This first claim is more than likely due to the fact that the body has a high level of natural testosterone as well as that provided by the use of AAS, and the second may be somewhat justifiable, as stimulating the testes to secrete testosterone intermittently may aid recovery. Perhaps this is due to the maintenence of a higher level of Inter-Testicular-Testosterone (ITT) provided by the intermittent use of HCG, which should greatly aid recovery of the hypothalamic-testicular-pituitary-axis. An average dose of HCG during a cycle is between 500iu to 1000iu every week to every other week while on a cycle.
As regards HCG´s use of Post-Cycle-Therapy (PCT), smaller and more frequent doses after a cycle of AAS would give the best results with the least amount of side effects. A dose of 250iu to 500iu everyday (ed) for 2 to 3 weeks is plenty and should very little from person to person. The Physicians Desk Reference recommends 500iu/day, as did the late, great, Dan Duchaine. The smaller doses are sufficient enough to begin reversal of testicular atrophy and used in conjunction with nolvade, will help the already present problem of recovery without raising the levels of estrogen to high and increasing the risk of gynecomastia in the user. Lower doses of 250iu to 500iu also avoid the further risk of down regulating LH receptors in the testes. The old saying more is better definitely does not apply to the use of HCG. You don´t want to finish PCT after using too much HCG only to find out your back at the beginning again. Your best bet is to start at 250iu or 500iu ed for 5 or 6 days, and if you don´t notice anything happening (nuts dropping and getting bigger) up the dose slightly. Small doses like 500iu two days a week isn´t going to cut it like some people think. The only thing small doses of HCG ay be useful (sublingually) for is reducing symptoms of benign prostatic hyperplasia. Yeah, that´s right, you can probably reduce some symptoms of an enlarged prostate with the use of small doses of HCG.
As stated above the cycles of HCG should be in the 2 to 3 week range with a least one month off in between, you could stretch your cycle out to four weeks without any major concern if you are using lower doses. One should however take care when using HCG as prolonged use could repress the body´s natural production of gonadotropins permanently, but this is mostly just pure speculation as it does not have yet to be reported nor has there been a case of an overdose. To be on the safe side shorter cycles of HCG seem to be that of the norm. Most users cycle HCG near the end of a steroid cycle, you should start your HCG therapy on the last week of your cycle. For best results you should also run nolva while you run HCG as taking HCG by itself will do little to nothing and gyno even though rare may also flair up. Once the HCG cycle is finished you continue with your usual clomid or nolvadex (preferably the latter) for pct as it is more effective when used in conjunction HCG for pct. With an AAS cycle of 6 to 10 weeks HCG may not be necessary unless extreme doses of AAS were used or there is an existing problem of testicular atrophy or you are running a heavy oral only cycle. AAS cycles of 12 or more weeks should have HCG as a part of post cycle plan.